Diethyl Ether → HCID 178440148, compound

HRID 53043Notes

Reaction equation

HRID 53043 reaction equation
[CH2:1]([C:4]1[NH:5][C:6]([C:11]#N)=[C:7]([C:9]#[N:10])[N:8]=1)[CH2:2][CH3:3].[CH:13]([Mg]I)([CH3:15])[CH3:14].C([O:20]CC)C>>[C:11]([C:6]1[N:5]=[C:4]([CH2:1][CH2:2][CH3:3])[NH:8][C:7]=1[C:9]#[N:10])(=[O:20])[CH:13]([CH3:15])[CH3:14]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 27637212-propyl-1H-imidazole-4,5-dicarbonitrileHCID 178461735HCID 178461735, compound

Product 1

HCID 178440148HCID 178440148, compound

Procedure

Following a procedure similar to that described in Preparation 23(i), but using 8.24 g of 2-propylimidazole-4,5-dicarbonitrile (prepared as described in Preparation 10) and 103 ml of a 2M solution of isopropylmagnesium iodide in diethyl ether, 45.0 g of the title compound were obtained as crystals, melting at 90.5°-91° C.

Sources & evidence

ORD record
ord-32940677fdca4e678ac8efc29a977a23
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Reaction notes

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