反应详情

(S)—N-Boc-2-morpholine carboxylic acid (2.00 g, 8.65 mmol) was dissolved in THF (30 mL) and borane (25.9 mL, 1.0 M in THF, 25.9 mmol) was added dropwise. The reaction mixture was heated at reflux for 2.5 h and quenched with water (10 mL). The reaction mixture was concentrated in vacuo and the residue dissolved in DCM (30 mL), washed with sat aq Na2CO3 (2×20 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (1.74 g, 92%) as a pale yellow oil. LCMS (ES+): 240.3 [MNa]+.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 2.5 h
3. customquenched with water (10 mL)
4. concentrationThe reaction mixture was concentrated in vacuo
5. dissolutionthe residue dissolved in DCM (30 mL)
6. washwashed with sat aq Na2CO3 (2×20 mL)
7. dry with materialdried (MgSO4)
8. concentrationconcentrated in vacuo