Hydrochloric Acid → Diethyl 2-ethoxymethylimidazole-4,5-dicarboxylate

HRID 53051Notes

Reaction equation

C([N:8]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:10]=[C:9]1[CH2:23][O:24][CH2:25][CH3:26])C1C=CC=CC=1.Cl>>[CH2:25]([O:24][CH2:23][C:9]1[NH:10][C:11]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:8]=1)[CH3:26]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19036277Diethyl 1-benzyl-2-ethoxymethylimidazole-4,5-dicarboxylate

Product 1

HCID 19036215Diethyl 2-ethoxymethylimidazole-4,5-dicarboxylate

Procedure

Following a procedure similar to that described in Preparation 42(iv), but using 4.37 g of diethyl benzyl-2-ethoxymethylimidazole-4,5-dicarboxylate [prepared as described in step (i) above], 3.49 g of the hydrochloride of the title compound were obtained as crystals, melting at 60°-61° C.

Sources & evidence

ORD record: ord-cd8d3e1bfe194ee8b7c6a4af14a735ec
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05616599

Reaction notes

Loading…