ethyl (2S*,3R*)-2-amino-3-hydroxy-pentanoate → (2S,3R)-3-Hydroxynorvaline

Temperature

130 °C

In a 35 ml microwave vial, ethyl (2S*,3R*)-2-amino-3-hydr oxy-pentanoate (0.078 g, 0.48 mmol) was dissolved in a 6.0 M HCl aqueous solution (7.0 mL) and stirred at 130° C. for 30 min. The reaction mixture was concentrated under reduced pressure and the resulting yellowish solid was used without further purification in the following step. MS (ESI) m/z: 134 [M−H]+; (ESI) m/z: 132 [M−H]−.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe resulting yellowish solid was used without further purification in the following step

ORD record

ord-00dc41e198ae406189081b82ed23bc8a

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09353075B2