反应详情

A mixture of 5 g (27.74 mmol) of methyl(3-methoxyphenyl)acetate, 5.2 g (29.14 mmol) of N-bromosuccinimide and a catalytic amount of AIBN in tetrachloromethane (50 ml) was heated under reflux with stirring for 2 h. The cooled reaction solution was filtered and washed with a small volume of dichloromethane. The combined filtrate and wash was concentrated in vacuo to afford methyl 2-bromo-2-(3-methoxyphenyl)acetate as an oil. Used as is in the next step.

1. temperatureunder reflux
2. customThe cooled reaction solution
3. filtrationwas filtered
4. washwashed with a small volume of dichloromethane
5. washThe combined filtrate and wash
6. concentrationwas concentrated in vacuo