Einecs 211-027-4 → HCID 178431895, compound

HRID 530757Notes

Reaction equation

HRID 530757 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([C:9]2[S:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=2)[N:6]=[C:5]([C:18]2[S:19][CH:20]=[C:21]([CH3:23])[N:22]=2)[CH:4]=1.[Cl-].[NH+]1C=CC=CC=1>O>[CH3:23][C:21]1[N:22]=[C:18]([C:5]2[CH:4]=[C:3]([OH:2])[CH:8]=[C:7]([C:9]3[S:10][CH:11]=[C:12]([C:14]([F:16])([F:15])[F:17])[N:13]=3)[N:6]=2)[S:19][CH:20]=1

Participants

4

Reactant 2

HCID 69401Einecs 211-027-4HCID 681599974-Methoxy-2-(4-methyl-thiazol-2-yl)-6-(4-trifluoromethyl-thiazol-2-yl)-pyridine

Product 1

HCID 178431895HCID 178431895, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
200 °C

Procedure

A mixture of compound 22 (1.68 mmol) and pyridinium chloride (5 g/mmol) was heated at 200° C. with stirring. After 30 min, the reaction mixture was cooled down to room temperature and H2O was added. The solid was collected, washed with H2O, and dried to give compound 23 as a grey solid in 72% yield. MS (ESI, EI+): m/z=343.85 (MH+

Workup

  1. temperaturethe reaction mixture was cooled down to room temperature
  2. customThe solid was collected
  3. washwashed with H2O
  4. customdried

Sources & evidence

ORD record
ord-079761f1ada8495e84cf02a2d56ba7ad
Source dataset
uspto-grants-2016_05
Patent number
US09353100B2

Reaction notes

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