HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (1,3-dimethyl-1H-pyrazol-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)methanamine hydrochloride | HCID 90419183 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (1,3-dimethyl-1H-pyrazol-4-yl)methanamine | HCID 1257622 | — |
Reaction Steps
To a solution of compound 4 (120 mg, 0.61 mmol) in THF (5 mL) was added LAH (43 mg, 3.78 mmol). The resulting mixture was stirred at room temperature overnight. Water was added and the resulting mixture was filtered. Organic layer was separated and then concentrated in vacuum to give a white solid (crude product). LCMS (ESI) m/z=126 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353104B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-a602945824aa427dbe9dfe180f482602 |
| Source note | uspto-grants-2016_05 |