Water → (1,3-dimethyl-1H-pyrazol-4-yl)methanamine

HRID 530795Notes

Reaction equation

HRID 530795 reaction equation
Cl.Cl[C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[CH2:10][NH2:11].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>C1COCC1>[CH3:8][N:7]1[CH:3]=[C:4]([CH2:10][NH2:11])[C:5]([CH3:9])=[N:6]1

Participants

5

Reactant 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 90419183(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)methanamine hydrochloride

Product 1

HCID 1257622(1,3-dimethyl-1H-pyrazol-4-yl)methanamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of compound 4 (120 mg, 0.61 mmol) in THF (5 mL) was added LAH (43 mg, 3.78 mmol). The resulting mixture was stirred at room temperature overnight. Water was added and the resulting mixture was filtered. Organic layer was separated and then concentrated in vacuum to give a white solid (crude product). LCMS (ESI) m/z=126 (M+H)+.

Workup

  1. filtrationthe resulting mixture was filtered
  2. customOrganic layer was separated
  3. concentrationconcentrated in vacuum
  4. customto give a white solid (crude product)

Sources & evidence

ORD record
ord-a602945824aa427dbe9dfe180f482602
Source dataset
uspto-grants-2016_05
Patent number
US09353104B2

Reaction notes

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