Ammonia → (2,6-Dimethylpyridin-3-yl)methanamine

HRID 530798Notes

Reaction equation

HRID 530798 reaction equation
Cl[CH2:2][C:3]1[C:4]([CH3:10])=[N:5][C:6]([CH3:9])=[CH:7][CH:8]=1.[NH3:11]>>[CH3:10][C:4]1[C:3]([CH2:2][NH2:11])=[CH:8][CH:7]=[C:6]([CH3:9])[N:5]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 628306083-(Chloromethyl)-2,6-dimethylpyridine

Product 1

HCID 21065647(2,6-Dimethylpyridin-3-yl)methanamine

Procedure

The solution of 3-(chloromethyl)-2,6-dimethylpyridine (850 mg, 5.5 mmol) in ammonia solution (10 mL) was stirred at 90° C. for 2 hours and then concentrated to give the crude product which was used for next step directly without further purification. LCMS (ESI) m/z=137.1 (M+H)+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-7da4fda518304ba69f8a1c03d4ea69fe
Source dataset
uspto-grants-2016_05
Patent number
US09353104B2

Reaction notes

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