反应详情

A suspension of 0.14 g of sodium borohydride in 10 ml of 1,2-dimethoxyethane was treated at 0° C. with a solution of 4-(4'-[(R)-2-octyl]oxycarbonyl-4-biphenylyl)cyclohexanone in 10 ml of 1,2-dimethoxyethane. The reaction mixture was stirred at room temperature for a further 30 minutes and then treated with 25% hydrochloric acid. The reaction mixture was extracted three times with 50 ml of diethyl ether each time. The combined organic phases were washed with sodium hydrogen carbonate solution and several times with water and subsequently dried over magnesium sulfate, filtered and concentrated. The residue was recrystallized twice from hexane and gave 0.8 g of trans-4-(4'-[(R)-2-octyl]oxycarbonyl 4-biphenylyl)cyclohexanol.

1. extractionThe reaction mixture was extracted three times with 50 ml of diethyl ether each time
2. washThe combined organic phases were washed with sodium hydrogen carbonate solution and several times with water
3. dry with materialsubsequently dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was recrystallized twice from hexane