Phosphorus tribromide → 3-(Bromomethyl)pyrazolo[1,5-a]pyridine

HRID 530809Notes

Reaction equation

HRID 530809 reaction equation
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]2=[C:3]([CH2:10]O)[CH:2]=1.P(Br)(Br)[Br:13]>C(Cl)Cl>[Br:13][CH2:10][C:3]1[CH:2]=[N:1][N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=12

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 14134319Pyrazolo[1,5-a]pyridin-3-ylmethanol

Product 1

HCID 768522023-(Bromomethyl)pyrazolo[1,5-a]pyridine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of pyrazolo[1,5-a]pyridin-3-ylmethanol (2) (50 mg, 0.338 mmol) in DCM (2 mL) was added PBr3 (36.58 mg, 0.135 mmol) at room temperature for 30 min. The reaction solution was used in the next step.

Sources & evidence

ORD record
ord-11575ae34fdd45909ee7e4de3a874ed3
Source dataset
uspto-grants-2016_05
Patent number
US09353104B2

Reaction notes

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