Phosphorus tribromide → 5-(bromomethyl)-3-ethyl-1-methyl-1H-pyrazole

HRID 530824Notes

Reaction equation

HRID 530824 reaction equation
[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8]O)[N:5]([CH3:10])[N:4]=1)[CH3:2].P(Br)(Br)[Br:12]>C(Cl)Cl>[Br:12][CH2:8][C:6]1[N:5]([CH3:10])[N:4]=[C:3]([CH2:1][CH3:2])[CH:7]=1

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 23005574(3-ethyl-1-methyl-1H-pyrazol-5-yl)methanol

Product 1

HCID 661209415-(bromomethyl)-3-ethyl-1-methyl-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 4 (500 mg, 3.57 mmol) in DCM (20 mL) was added PBr3 (386 mg, 1.43 mmol) was stirred at ° C. for 2 h. The mixture was washed with water, dried over Na2SO4. The solvent was evaporated to give the crude compound which was used in the next step without further purification.

Workup

  1. washThe mixture was washed with water
  2. dry with materialdried over Na2SO4
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-eada8e7c7393451a9f3883cce36f557a
Source dataset
uspto-grants-2016_05
Patent number
US09353104B2

Reaction notes

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