HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 5-(bromomethyl)-3-ethyl-1-methyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (3-ethyl-1-methyl-1H-pyrazol-5-yl)methanol | HCID 23005574 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(bromomethyl)-3-ethyl-1-methyl-1H-pyrazole | HCID 66120941 | — |
Reaction Steps
To a solution of compound 4 (500 mg, 3.57 mmol) in DCM (20 mL) was added PBr3 (386 mg, 1.43 mmol) was stirred at ° C. for 2 h. The mixture was washed with water, dried over Na2SO4. The solvent was evaporated to give the crude compound which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353104B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-eada8e7c7393451a9f3883cce36f557a |
| Source note | uspto-grants-2016_05 |