Azane;hydrate → (3-Ethyl-1-methyl-1H-pyrazol-5-yl)methanamine

HRID 530825Notes

Reaction equation

HRID 530825 reaction equation
Br[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH2:9][CH3:10])[CH:4]=1.[NH3:11].O>>[CH2:9]([C:5]1[CH:4]=[C:3]([CH2:2][NH2:11])[N:7]([CH3:8])[N:6]=1)[CH3:10]

Participants

3

Reactant 2

HCID 12896473Azane;hydrateHCID 661209415-(bromomethyl)-3-ethyl-1-methyl-1H-pyrazole

Product 1

HCID 23006075(3-Ethyl-1-methyl-1H-pyrazol-5-yl)methanamine

Procedure

A solution of compound 5 (660 mg, 3.27 mmol) in NH3.H2O (5 mL) was stirred at 90° C. for 3 h. The solvent was evaporated to give the crude product as a white solid which was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-0c8ed6d935c14741b775cb62fa8cff82
Source dataset
uspto-grants-2016_05
Patent number
US09353104B2

Reaction notes

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