HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 4-bromo-2-(4-methoxybenzyl)-6-(((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methoxy)pyridazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| Reactant | ((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methanol | HCID 66834134 | — |
| Reactant | 5-Bromo-1-(4-methoxybenzyl)-1,2-dihydropyridazine-3,6-dione | HCID 90419128 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-bromo-2-(4-methoxybenzyl)-6-(((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methoxy)pyridazin-3(2H)-one | HCID 90419326 | — |
Reaction Steps
DIAD (0.625 ml, 3.21 mmol) was added to a mixture of 5-bromo-1-(4-methoxybenzyl)-1,2-dihydropyridazine-3,6-dione (500 mg, 1.607 mmol), ((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methanol (288 mg, 1.607 mmol) and PPh3 (843 mg, 3.21 mmol) in THF (15 ml) at 0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353104B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-9a3428a0d918483ebc9ab013be39b51c |
| Source note | uspto-grants-2016_05 |