HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-Fluoro-3-(2-fluorobenzyl)cyclohexanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (Bis(2-methoxyethyl)amino)sulfur trifluoride | HCID 2734690 | — |
| Reactant | Tert-butyl 3-(2-fluorobenzyl)-3-hydroxycyclohexylcarbamate | HCID 67983409 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Fluoro-3-(2-fluorobenzyl)cyclohexanamine | HCID 67983647 | — |
Reaction Steps
To a solution of tert-butyl-3-(2-fluorobenzyl)-3-hydroxycyclohexylcarbamate (1 mmol, 323 mg) in DCM was added Deoxo-Fluor® (2 mmol, 370 μL) at room temperature. The reaction mixture was stirred for overnight. Methanol was added dropwise. The desired product was obtained after the removal of solvent by rotary evaporation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09351965B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-5b06f5e43d6e4546bc88e39dc0acf5ed |
| Source note | uspto-grants-2016_05 |