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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 530855Generated: October 30, 2026

Hydrochloric Acid → 3-Fluoro-3-(2-fluorobenzyl)cyclohexanamine

https://huagongshe.com/reaction/530855

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactanttert-Butyl-3-fluoro-3-(2-fluorobenzyl)cyclohexylcarbamateHCID 68073629—
Solvent1,4-DioxaneHCID 31275—
Product3-Fluoro-3-(2-fluorobenzyl)cyclohexanamineHCID 67983647—

Reaction Steps

tert-Butyl-3-fluoro-3-(2-fluorobenzyl)cyclohexylcarbamate was reacted with HCl in dioxane (4 M) at room temperature. After stirring for overnight, 3-fluoro-3-(2-fluorobenzyl)cyclohexanamine was obtained after the removal of solvent by rotary evaporation.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09351965B2
Source datasetuspto-grants-2016_05
ORD IDord-8fdab3b4c0ee44a2ba9e6516362d07a5
Source noteuspto-grants-2016_05