Hydrochloric Acid → 3-Fluoro-3-(2-fluorobenzyl)cyclohexanamine

HRID 530855Notes

Reaction equation

HRID 530855 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][C:10]([F:22])([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[F:22][C:10]1([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[CH2:11][CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68073629tert-Butyl-3-fluoro-3-(2-fluorobenzyl)cyclohexylcarbamate

Product 1

HCID 679836473-Fluoro-3-(2-fluorobenzyl)cyclohexanamine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl-3-fluoro-3-(2-fluorobenzyl)cyclohexylcarbamate was reacted with HCl in dioxane (4 M) at room temperature. After stirring for overnight, 3-fluoro-3-(2-fluorobenzyl)cyclohexanamine was obtained after the removal of solvent by rotary evaporation.

Sources & evidence

ORD record
ord-8fdab3b4c0ee44a2ba9e6516362d07a5
Source dataset
uspto-grants-2016_05
Patent number
US09351965B2

Reaction notes

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