反应详情

A mixture of tert-butyl 3-(hydroxymethyl)cyclohexylcarbamate (7.9 mmol), methanesulfonyl chloride (23.7 mmol) and triethylamine (119 mmol) in DCM (100 ml) was stirred at rt overnight. The reaction was quenched with water (50 mL) and extracted with ethyl acetate (3×100 mL). The extracts were combined, dried using anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude product was progressed to the next step without purification.

1. customThe reaction was quenched with water (50 mL)
2. extractionextracted with ethyl acetate (3×100 mL)
3. customdried
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe crude product was progressed to the next step without purification