HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-(3-((1H-indazol-1-yl)methyl)cyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-(3-((1H-indazol-1-yl)methyl)cyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide | HCID 67985189 | — |
| Catalyst | Triethylsilane | HCID 12052 | — |
| Product | N-(3-((1H-indazol-1-yl)methyl)cyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide | HCID 67985939 | — |
Reaction Steps
Trifluoroacetic acid (5 mL) was added to N-(3-((1H-indazol-1-yl)methyl)cyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide (0.1 mmol). The reaction was stirred at room temperature for 30 minutes. Triethylsilane (1 drop) was added to the reaction and stirred for an additional 5 minutes. The crude product purified using prep HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09351965B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-e2cdba07d9b94b51a8d37184f8ed071b |
| Source note | uspto-grants-2016_05 |