HRID530870

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ccc(C(=O)NC4CCCC(Cn5ncc6ccccc65)C4)cc23)ccn1

HCID67985189

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(-c2n[nH]c3ccc(C(=O)NC4CCCC(Cn5ncc6ccccc65)C4)cc23)ccn1

HCID67985939

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID12052

Silane, triethyl-

C6H16Si

PROCEDURE

实验过程

Trifluoroacetic acid (5 mL) was added to N-(3-((1H-indazol-1-yl)methyl)cyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide (0.1 mmol). The reaction was stirred at room temperature for 30 minutes. Triethylsilane (1 drop) was added to the reaction and stirred for an additional 5 minutes. The crude product purified using prep HPLC.

WORKUP

后处理

stirringstirred for an additional 5 minutes
customThe crude product purified

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e2cdba07d9b94b51a8d37184f8ed071b
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09351965B2
来源说明: uspto-grants-2016_05

反应 SMILES

FC(F)(F)C(O)=O.[N:8]1([CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH:20]([NH:24][C:25]([C:27]3[CH:28]=[C:29]4[C:33](=[CH:34][CH:35]=3)[N:32](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:31]=[C:30]4[C:55]3[CH:60]=[CH:59][N:58]=[C:57]([CH3:61])[CH:56]=3)=[O:26])[CH2:19]2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[N:9]1>C([SiH](CC)CC)C>[N:8]1([CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH:20]([NH:24][C:25]([C:27]3[CH:28]=[C:29]4[C:33](=[CH:34][CH:35]=3)[NH:32][N:31]=[C:30]4[C:55]3[CH:60]=[CH:59][N:58]=[C:57]([CH3:61])[CH:56]=3)=[O:26])[CH2:19]2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[N:9]1