反应详情

In a flask, methyl 1-(4-fluorobenzyl)-3-(3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamido)cyclohexanecarboxylate (0.31 mmol) was dissolved in tetrahydrofuran (6 mL). Lithium aluminum hydride in THF (1M) (0.62 ml, 0.62 mmol) was added to the flask. The reaction was stirred for 3 hrs at room temperature. Upon completion, the reaction was quenched with ethyl acetate (5 ml) drop-wise. Water (5 mL) was added to the reaction. The reaction mixture then was extracted 3 times with ethyl acetate (20 mL). The organic layers were combined, were dried with sodium sulfate, concentrated and purified using HPLC to give the titled compound. LC-MS: 473.23 [M+H]. LC/MS RT=2.46 min.

1. customUpon completion, the reaction was quenched with ethyl acetate (5 ml) drop-wise
2. additionWater (5 mL) was added to the reaction
3. extractionThe reaction mixture then was extracted 3 times with ethyl acetate (20 mL)
4. dry with materialwere dried with sodium sulfate
5. concentrationconcentrated
6. custompurified