反应详情

In a flask, 1-tert-butyl 3-methyl 3-(2-fluorobenzyl)piperidine-1,3-dicarboxylate (1.41 g, 4.0 mmol) was dissolved in tetrahydrofuran (20 mL). Lithium aluminum hydride (8.03 mmol) was added to the flask. The reaction was stirred for an hour at room temperature. Upon completion, the reaction was quenched with ethyl acetate (10 ml) drop-wise. Water (30 mL) was added to the reaction. The reaction mixture then was extracted 3 times with ethyl acetate (50 mL). The organic layers were combined, were dried with sodium sulfate, concentrated and purified using flash chromatography (0 60% ethyl acetate in hexane) to give the titled compound (1.29 g).

1. customUpon completion, the reaction was quenched with ethyl acetate (10 ml) drop-wise
2. additionWater (30 mL) was added to the reaction
3. extractionThe reaction mixture then was extracted 3 times with ethyl acetate (50 mL)
4. dry with materialwere dried with sodium sulfate
5. concentrationconcentrated
6. custompurified