Hydrochloric Acid → (3-(2-Fluorobenzyl)piperidin-3-yl)methanol

HRID 530881Notes

Reaction equation

HRID 530881 reaction equation
Cl.[F:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][C:6]1([CH2:19][OH:20])[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1>O1CCOCC1>[F:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][C:6]1([CH2:19][OH:20])[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67983173HCID 67983173, compound

Product 1

HCID 56754765(3-(2-Fluorobenzyl)piperidin-3-yl)methanol

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Hydrochloric acid in dioxane (1.5 mL, 4M) was added to a flask containing tert-butyl 3-(2-fluorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxylate (0.43 g, 1.33 mmol). 1,4-dioxane (1.5 mL) was added to the reaction mixture. The reaction was allowed to stir for 4 hours. Upon reaction completion, the reaction was concentrated, and 346 mg of crude product was recovered and progressed to the next step without further purification.

Workup

  1. customUpon reaction completion
  2. concentrationthe reaction was concentrated
  3. custom346 mg of crude product was recovered
  4. customprogressed to the next step without further purification

Sources & evidence

ORD record
ord-d8fc6c7eb35a4955a9e29ca0a3a4ecf1
Source dataset
uspto-grants-2016_05
Patent number
US09351965B2

Reaction notes

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