Hydrochloric Acid → 3-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

HRID 530885Notes

Reaction equation

HRID 530885 reaction equation
Cl.[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1>O1CCOCC1>[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67982981tert-Butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate

Product 1

HCID 679832113-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Hydrochloric acid in dioxane (1.5 mL, 4M) was added to a flask containing tert-butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate (0.415 g, 1.23 mmol). 1,4-dioxane (1.5 mL) was added to the reaction mixture. The reaction was allowed to stir for 4 hours. Upon reaction completion, the reaction was concentrated, and 337 mg of crude product was recovered and progressed to the next step without further purification.

Workup

  1. customUpon reaction completion
  2. concentrationthe reaction was concentrated
  3. custom337 mg of crude product was recovered
  4. customprogressed to the next step without further purification

Sources & evidence

ORD record
ord-b356c715e813422683ff34ee5596f4b2
Source dataset
uspto-grants-2016_05
Patent number
US09351965B2

Reaction notes

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