反应详情

Manganese dioxide (60.4 g) was added to a mixture of (2-cyclopropyl-4′-fluoro-6-propoxybiphenyl-4-yl)methanol (29.8 g) and toluene (200 mL), and the resultant mixture was stirred at 60° C. for 1 hour in a nitrogen atmosphere. The reaction mixture was filtered, and then, the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (22.1 g).

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated
3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)