(2-Cyclopropyl-4'-fluoro-6-propoxybiphenyl-4-yl)methanol → 2-Cyclopropyl-4'-fluoro-6-propoxybiphenyl-4-carbaldehyde

Participants

Reaction Steps

Manganese dioxide (60.4 g) was added to a mixture of (2-cyclopropyl-4′-fluoro-6-propoxybiphenyl-4-yl)methanol (29.8 g) and toluene (200 mL), and the resultant mixture was stirred at 60° C. for 1 hour in a nitrogen atmosphere. The reaction mixture was filtered, and then, the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (22.1 g).

Provenance & Evidence