反应详情

A mixture of methyl 2-bromo-5-ethoxy-2′,4′-difluorobiphenyl-4-carboxylate (22.6 g), cyclopropylboronic acid (13.1 g), dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (3.75 g), a 2 M aqueous sodium carbonate solution (91 mL), tris(dibenzylideneacetone)dipalladium(0) (3.91 g), and toluene (150 mL) was stirred overnight at 100° C. in an argon atmosphere. The reaction mixture was allowed to cool to room temperature, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline and passed through a short silica gel (NH) column, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate). A THF (50 mL) solution of the purified product was added to a THF (50 mL) suspension of lithium aluminum hydride (2.5 g) under ice cooling in a nitrogen atmosphere. After stirring at the same temperature as above for 30 minutes, water (2.5 mL) and a 15% aqueous sodium hydroxide solution (2.5 mL) were added thereto, and the mixture was stirred for 5 minutes. Water (7.5 mL) was further added to the reaction mixture, and the mixture was stirred for 30 minutes and then filtered. The filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (16.1 g).

1. extractionfollowed by extraction with ethyl acetate
2. washThe organic layer was washed with saturated saline
3. distillationthe solvent was distilled off under reduced pressure
4. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)
5. additionA THF (50 mL) solution of the purified product was added to a THF (50 mL) suspension of lithium aluminum hydride (2.5 g) under ice cooling in a nitrogen atmosphere
6. additiona 15% aqueous sodium hydroxide solution (2.5 mL) were added
7. stirringthe mixture was stirred for 5 minutes
8. additionWater (7.5 mL) was further added to the reaction mixture
9. stirringthe mixture was stirred for 30 minutes
10. filtrationfiltered
11. concentrationThe filtrate was concentrated under reduced pressure
12. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)