HCID 68106018, compound → HCID 68106140, compound

HRID 531152Notes

Reaction equation

[C:1]([CH2:8][N:9]1[CH2:20][CH2:19][N:18]2[CH2:21][CH2:22][CH2:23][N:12]([CH2:13][CH2:14][N:15]([CH2:24][C:25]([O:27]C(C)(C)C)=[O:26])[CH2:16][CH2:17]2)[CH2:11][CH2:10]1)([O:3]C(C)(C)C)=[O:2]>Cl>[C:25]([CH2:24][N:15]1[CH2:14][CH2:13][N:12]2[CH2:23][CH2:22][CH2:21][N:18]([CH2:19][CH2:20][N:9]([CH2:8][C:1]([OH:3])=[O:2])[CH2:10][CH2:11]2)[CH2:17][CH2:16]1)([OH:27])=[O:26]

Participants

Conditions

Temperature: 100 °C

Procedure

Compound 5 (1.12 g, 2.54 mmol) was dissolved in 6 N HCl (60 mL), and slowly heated to 100° C. with stirring for 24 hours. After evaporation of all the solvents, the crude product was recrystallized from ethanol/diethyl ether to give white solid 6 (1.18 g, 98% yield) (4 equiv HCl calculated on the basis of mass).

Workup

customAfter evaporation of all the solvents
customthe crude product was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record: ord-06cb6608ebfd4acca258911b090c16cd
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09353120B2

Reaction notes

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