HCID 68106186, compound → Propylene

Participants

Reaction Steps

The synthetic intermediate 3 was deprotected by catalytic hydrogenation in EtOH solvent to give propylene cross-bridged cyclen 4. The precursor, propylene cross-bridged cyclen (1,4,7,10-tetraazabicyclo[5.5.3]pentadecane) with bis(t-butyl ester) pendant arms, being dialkylated with t-butyl bromoacetate and convenient to handle, was produced with high yield (85%) enough to be quantitated. The synthetic intermediate 5 was deprotected with trifluoroacetic acid in dichloromethane to give PCB-DO2A 6 as a bis(trifluoroacetic acid) salt. This synthesis procedure of PCB-DO2A according to an embodiment of the present disclosure is remarkably improved over the existing cross-bridged cyclen synthesis method in terms of overall yield (57%), simple procedure, selectivity, or the like.

Provenance & Evidence