HCID 68106018, compound → HCID 68106140, compound

HRID 531155Notes

Reaction equation

HRID 531155 reaction equation
[C:1]([CH2:8][N:9]1[CH2:20][CH2:19][N:18]2[CH2:21][CH2:22][CH2:23][N:12]([CH2:13][CH2:14][N:15]([CH2:24][C:25]([O:27]C(C)(C)C)=[O:26])[CH2:16][CH2:17]2)[CH2:11][CH2:10]1)([O:3]C(C)(C)C)=[O:2]>C(C(O)=O)(F)(F)F.C(Cl)Cl>[C:25]([CH2:24][N:15]1[CH2:14][CH2:13][N:12]2[CH2:23][CH2:22][CH2:21][N:18]([CH2:19][CH2:20][N:9]([CH2:8][C:1]([OH:3])=[O:2])[CH2:10][CH2:11]2)[CH2:17][CH2:16]1)([OH:27])=[O:26]

Participants

4

Reactant 1

HCID 68106018HCID 68106018, compound

Product 1

HCID 68106140HCID 68106140, compoundYield 166.2%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

Compound 5 (1.25 g, 2.84 mmol) was dissolved in a 1:1 (vol:vol) mixture of CF3CO2H (TFA) and CH2Cl2 (45 mL). The mixture was stirred at room temperature for 24 hours. The solvent was removed under reduced pressure to give an oily residue which was triturated with Et2O to provide white solid 6 (1.55 g, 98% yield).

Workup

  1. customThe solvent was removed under reduced pressure
  2. customto give an oily residue which
  3. customwas triturated with Et2O

Sources & evidence

ORD record
ord-b0c80ad7a3834ecf848cae8869b69adf
Source dataset
uspto-grants-2016_05
Patent number
US09353120B2

Reaction notes

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