Hydrazine hydrate (1:1) → HCID 59774522, compound

HRID 531180Notes

Reaction equation

HRID 531180 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[N:6]=[C:7](Cl)[C:8]2[S:13][CH:12]=[C:11]([CH3:14])[C:9]=2[N:10]=1>CCO>[Cl:4][C:5]1[N:6]=[C:7]([NH:2][NH2:3])[C:8]2[S:13][CH:12]=[C:11]([CH3:14])[C:9]=2[N:10]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 71470642,4-Dichloro-7-methylthieno(3,2-d)pyrimidine

Product 1

HCID 59774522HCID 59774522, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine monohydrate (2.21 mL; 45.6 mmol; 2.0 equiv) was added to a suspension of 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine (5 g; 22.8 mmol; 1.0 equiv) in 40 mL of EtOH. The reaction was stirred at ambient temperature for 2 days. The solid was filtered, washed with H2O and dried to give 2-chloro-4-hydrazino-7-methylthieno[3,2-d]pyrimidine as an off-white solid (4.4 g; 90% yield); MS (ES) 214.97 (M+H), 212.99 (M−H).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with H2O
  3. customdried

Sources & evidence

ORD record
ord-01fa23b756774445b16d4fb8d962444d
Source dataset
uspto-grants-2016_05
Patent number
US09353126B2

Reaction notes

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