反应详情

温度

25 °C

Potassium peroxymonosulfate (972 mg, 1.581 mmol) was added to an acetonitrile (4 mL)/water (2 mL) solution of (4S,5R)-3-{[5-(5-chloro-2-methoxypyridin-3-yl)-2-(methylthio)pyrimidin-4-yl]methyl}-4-methyl-5-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidin-2-one (INTERMEDIATE 19, 380 mg, 0.702 mmol) at 25° C. The reaction was stirred for 16 hours at 25° C. followed by dilution with 100 mL methyl-t-butyl ether and 100 mL water. The organic layer was washed with 100 mL of aqueous NaCl three times. The organic layer was dried over sodium sulfate, filtered and the filtrate concentrated to give the title compound as a white solid, which can be used without further purification. LCMS (M+H)+: 573.3.

1. washThe organic layer was washed with 100 mL of aqueous NaCl three times
2. dry with materialThe organic layer was dried over sodium sulfate
3. filtrationfiltered
4. concentrationthe filtrate concentrated