HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-(4-tert-Butylthiazol-2-yl)-3-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 4-(4-tert-butylthiazol-2-yl)-3-methylbenzoate | HCID 90009157 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(4-tert-Butylthiazol-2-yl)-3-methylbenzoic acid | HCID 90009134 | — |
Reaction Steps
Methyl 4-(4-tert-butylthiazol-2-yl)-3-methylbenzoate (Step A, 7.3 g, 25.2 mmole) was stirred with lithium hydroxide (1.5 g, 63.5 mmol) in 20 mL of 1,4-dioxane and 10 mL of water for 3 hours. It was concentrated to dryness to collect 4-(4-tert-butylthiazol-2-yl)-3-methylbenzoic acid as a white solid. This was used in the next step without any further purification. LCMS (M+H)+: 276.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353101B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-a68bef4ac13949f792d82abd50e5c8da |
| Source note | uspto-grants-2016_05 |