反应详情

Methyl 4-(4-tert-butylthiazol-2-yl)-3-methylbenzoate (Step A, 7.3 g, 25.2 mmole) was stirred with lithium hydroxide (1.5 g, 63.5 mmol) in 20 mL of 1,4-dioxane and 10 mL of water for 3 hours. It was concentrated to dryness to collect 4-(4-tert-butylthiazol-2-yl)-3-methylbenzoic acid as a white solid. This was used in the next step without any further purification. LCMS (M+H)+: 276.0

1. concentrationIt was concentrated to dryness
2. customto collect 4-(4-tert-butylthiazol-2-yl)-3-methylbenzoic acid as a white solid
3. customThis was used in the next step without any further purification