HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → {4-[3-Bromo-2,2-bis(hydroxymethyl)propoxy]phenyl}(phenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | (4-{[3-(Hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone | HCID 89906737 | — |
| Solvent | Water | HCID 962 | — |
| Product | {4-[3-Bromo-2,2-bis(hydroxymethyl)propoxy]phenyl}(phenyl)methanone | HCID 89907389 | — |
Reaction Steps
Suspend (4-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone in a mixture of 48% aq. HBr and water and heat the mixture to reflux for 1 hour. Extract the product into dichloromethane, and evaporate the solvent, the solid residue may be recrystallised from ethanol to provide {4-[3-bromo-2,2-bis(hydroxymethyl)propoxy]phenyl}(phenyl)methanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353211B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-693fb41c2ad141b39f5477b97ee2c183 |
| Source note | uspto-grants-2016_05 |