反应详情

Suspend (4-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone in a mixture of 48% aq. HBr and water and heat the mixture to reflux for 1 hour. Extract the product into dichloromethane, and evaporate the solvent, the solid residue may be recrystallised from ethanol to provide {4-[3-bromo-2,2-bis(hydroxymethyl)propoxy]phenyl}(phenyl)methanone.

1. temperatureheat the mixture
2. temperatureto reflux for 1 hour
3. extractionExtract the product into dichloromethane
4. customevaporate the solvent
5. customthe solid residue may be recrystallised from ethanol