反应详情

Dissolve the {4-[3-bromo-2,2-bis(hydroxymethyl)propoxy]phenyl}(phenyl)methanone obtained in the previous stage in ethanol and treat it with excess of 40% aq. dimethylamine at reflux for 8 h. Remove the solvent in vacuo and purify the residue by column chromatography to provide the desired 2-(4-benzoylphenoxymethyl)-2-[(dimethylamino)methyl]propane-1,3-diol.

1. temperatureat reflux for 8 h
2. customRemove the solvent in vacuo
3. custompurify the residue by column chromatography