HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 2-(4-Benzoylphenoxymethyl)-2-[(dimethylamino)methyl]propane-1,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | {4-[3-Bromo-2,2-bis(hydroxymethyl)propoxy]phenyl}(phenyl)methanone | HCID 89907389 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Benzoylphenoxymethyl)-2-[(dimethylamino)methyl]propane-1,3-diol | HCID 89908373 | — |
Reaction Steps
Dissolve the {4-[3-bromo-2,2-bis(hydroxymethyl)propoxy]phenyl}(phenyl)methanone obtained in the previous stage in ethanol and treat it with excess of 40% aq. dimethylamine at reflux for 8 h. Remove the solvent in vacuo and purify the residue by column chromatography to provide the desired 2-(4-benzoylphenoxymethyl)-2-[(dimethylamino)methyl]propane-1,3-diol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353211B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-40e4cc2a140846ec80f53c973e568b26 |
| Source note | uspto-grants-2016_05 |