反应详情

Using similar reaction conditions as described in step-iii of example-1, N-(3-(3-(1-(4-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methane sulfonamide (137 mg, 0.222 mmol) was hydrolyzed with lithium hydroxide (47 mg, 1.111 mmol) in THF/water/methanol (12/6/3 ml) mixture to afford 1 mg (1% yield) of the title compound. 1H NMR (CD3OD, 600 MHz): δ 8.48 (br, 1H), 8.365-8.361 (d, 1H), 8.183 (s, 1H), 7.922 (s, 1H), 7.64 (s, 1H), 7.568 (m, 1H), 7.52-7.50 (m, 2H), 7.48-7.44 (m, 1H), 7.37-7.34 (m, 2H), 7.31-7.29 (m, 1H), 7.127-7.083 (m, 2H), 5.411 (s, 2H), 3.025 (s, 3H). MS: m/z=462.4 (M+1), HPLC: 90.99% in method B.

1. customreaction conditions