HRID531549
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
产物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Using similar reaction conditions as described in step-iii of example-1, 4-(4-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl) morpholine (100 mg, 0.157 mmol) was hydrolyzed by lithium hydroxide (33 mg, 0.786 mmol), THF/Methanol/water (5/5/3 ml) to afford 24 mg (32% yield) of the titled compound. 1H NMR (CDCl3, 300 MHz): δ 9.36 (s, 1H), 8.56 (s, 1H), 7.87 (s, 1H), 7.75-7.52 (d, 2H), 7.40-7.30 (m, 1H), 7.10-6.95 (m, 3H), 6.90-6.80 (d, 1H), 5.32 (s, 2H), 3.91-3.88 (m, 4H), 3.23-3.20 (m, 4H), 2.26 (s, 3H), 2.15 (s, 3H). MS: m/z=482.3 (M+1), HPLC Purity: 99.13% Method: B.
WORKUP
后处理
- customreaction conditions