tert-butyl 3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-5-(6-methoxy-5-(methyl sulfonamido)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate → HCID 178433947, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-5-(6-methoxy-5-(methylsulfonamido)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (61 mg, 0.098 mmol) was deprotected in HCl in MeOH (3 ml) to afford 5 mg (11.3% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.71-8.62 (d, 2H), 7.91-7.88 (d, 2H), 7.68 (s, 1H), 7.47-7.42 (m, 1H), 7.15-7.02 (m, 3H), 6.60 (s, 1H), 5.57 (s, 2H), 3.09 (s, 3H), 2.36 (s, 3H), 2.35 (s, 3H). MS: m/z=506.8 (M+1), HPLC: 90.22% in method B.

Provenance & Evidence