反应详情

Using similar reaction conditions as described in step-iii of example-1, 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (180 mg, 0.291 mmol) was hydrolyzed by lithium hydroxide (37 mg, 0.874 mmol) in THF/methanol/water (2/2/2 ml) to yield crude 230 mg of the titled compound.

1. customreaction conditions