反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(3-methylbenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (164 mg, 0.233 mmol) was hydrolyzed by lithium hydroxide (98 mg, 2.33 mmol) in THF/methanol/water (16/4/4 ml) to yield crude 109 mg (86% yield) of the titled compound after column purification using 1.5% methanol in DCM as eluent. MS: m/z=548.4 (M+1).

1. customreaction conditions