反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methoxyphenyl)piperidine-1-carboxylate (200 mg, 0.271 mmol) was hydrolyzed by lithium hydroxide (57 mg, 1.358 mmol) in THF/methanol/water (5/2/2 ml) to yield crude 100 mg (63.2% yield) of the titled compound. MS: m/z=582.2 (M+1).

1. customreaction conditions