反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (150 mg, 0.217 mmol) was hydrolyzed by lithium hydroxide (27 mg, 0.653 mmol) in THF/methanol/water (3/3/3 ml) to yield crude 120 mg (crude) of the titled compound. MS: m/z=532.9 (M+1).

1. customreaction conditions