反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-3-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (100 mg, 0.138 mmol) was hydrolyzed by lithium hydroxide (17 mg, 0.416 mmol) in THF/methanol/water (2/2/1 ml) to yield 100 mg (crude) of the titled compound.

1. customreaction conditions