反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (140 mg, 0.203 mmol) was hydrolyzed by lithium hydroxide (44 mg, 1.04 mmol) in THF/methanol/water (4/4/2 ml) to yield 110 mg (98.5% yield) of the titled compound. MS: m/z=535.3 (M+1).

1. customreaction conditions