Hydrochloric Acid → 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(piperazin-1-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridinehydrochloride

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Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (step 1, example 39) (370 mg, 0.52 mmol) was deprotected in ether (5 ml) and HCl in ether (3 ml). This afforded 270 mg (80.35% yield) of the titled compound. MS: m/z=607.2 (M+1).

Provenance & Evidence