反应详情

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (step 1, example 39) (370 mg, 0.52 mmol) was deprotected in ether (5 ml) and HCl in ether (3 ml). This afforded 270 mg (80.35% yield) of the titled compound. MS: m/z=607.2 (M+1).

1. customreaction conditions